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Ultrasound Wherever You Go

Date: Jun 15, 2023
Tags: wearable, biotechnology, ultrasound, electrical, heart, crystal, piezoelectric
 

What is ultrasound and how does it currently work?

Ultrasound, or sonography, uses sound waves to map structures inside the human body. Although pregnancy comes to mind when talking about ultrasound, ultrasound has a variety of other uses such as diagnosing diseases, evaluating blood flow, guiding the needle during a biopsy, checking the thyroid gland, and observing joint inflammation.

Humans can hear sound frequencies ranging from 20 Hertz (Hz) to 20000Hz, but ultrasound is imperceptible to humans because it has a frequency above 20000 Hz. Ultrasound can be compared to sonar, the imaging method used by submarines to detect missiles or other ships around them.

Most ultrasound systems employ the use of a transducer, which is composed of an array of piezoelectric crystals. Transducers typically convert one form of energy into another, and the transducers used in ultrasound systems are no different. When electricity is applied an ultrasound transducer, it emits high frequency sound waves that bounce off of the variety of tissues in the human body. Based on the tissues' properties (density, smoothness, hardness), the waves are reflected with different frequencies and wavelengths. When these reflected waves reach the transducer again, another electrical current is generated, allowing the ultrasound to display a point.

Transducer demonstration
Each line of crystals in the piezoelectric crystal array produce a line of the final ultrasound image. This process repeats over and over again more than 1000 times per second, resulting in the video you see on the screen during an ultrasound. Obviously, since sound waves cannot transmit color (only light can do that), the image is only black and white. The brighter a pixel is, the more strongly the sound waves were reflected.

While transducers are usually placed above the body, there are instances in which it must be placed inside an opening:

  • Transesophageal echocardiograms requires the transducer to be inserted into the esophagus (throat) to get clear images of the heart.
  • Transrectal ultrasound is when the transducer is placed into the rectum to get images of the prostate.
  • Transvaginal ultrasounds are when a transducer is inserted into the vagina to observe the uterus and ovaries.

Once an ultrasound is complete, radiologists analyze the images for any signs of disease, helping cure or even prevent diseases.

So what is a wearable ultrasound?

Recently, scientists at the University of California, San Diego have created a wireless wearable ultrasound device that can create images of internal tissues while the patient moves around freely. While traditional ultrasounds require that the patient remain still and close to the handheld, wired device, this new wearable sticks to the body and can take useful measurements while patients exercise or conduct other activities.

Wearable, Courtesy of Muyang Lin and Nature Biotechnology
The new ultrasound device allows researchers to measure patients' blood pressure, heart health, and lung capacity accurately in real time. Its transducers can detect tissues less than 16 centimeter below the skin and has a high enough battery capacity to measure blood pressure, heart output, and respiratory health for 12 hours continuously without needing to charge again. This new device consists of a stretchable probe with a 32-channel array of piezoelectric transducers. Stretchable copper wires connect the transducers to a control circuit, which then sends the electric signals to a microcontroller. With the assistance of a Wi-Fi transmitter, the microcontroller converts the analog signal into a digital signal that is wirelessly sent to the connected smartphone.
Wearable Ultrasound Circuit Components, Courtesy of Muyang Lin and Nature Biotechnology
A machine-learning algorithm analyzes pulses from the carotid artery and jugular vein to determine the heart rate and blood pressure, contraction of the heart to determine the volume of blood that the heart can pump out, and motion of the diaphragm to calculate the respiration output/lung capacity. Since the wearer is continuously moving, some of the transducer's 32 channels may not have a clear image, so the best one is picked.